{"id":38,"date":"2021-10-12T19:18:22","date_gmt":"2021-10-12T10:18:22","guid":{"rendered":"http:\/\/antiage.sci.yokohama-cu.ac.jp\/?page_id=38"},"modified":"2026-04-23T15:57:21","modified_gmt":"2026-04-23T06:57:21","slug":"gyouseki","status":"publish","type":"page","link":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/gyouseki\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"\n

\u7814\u7a76\u696d\u7e3e<\/strong><\/p>\n\n\n\n

-\u8ad6\u6587\u767a\u8868-<\/strong><\/h3>\n\n\n\n

2025\u5e74<\/strong><\/p>\n\n\n\n

\u30fbYoshimi Yamakami, Kyoko Morino, Robert A. Kanaly, Raku Irie, Masato Oikawa, Yuki Takauji, Kensuke Miki, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii. 1,6-Digalloyl glucose in Emblica Officinalis<\/em> increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin. Biosci Biotechnol Biochem. 0 1-14, 2025\u5e748\u6708<\/strong><\/p>\n\n\n\n

\u30fbYuki Takauji, Keisuke Tanabe, Haruna Miyashita, Takuma Katakawa, Saeri Fujii, Atsuki En, Michihiko Fujii. Disturbed proteostasis is the key event that triggers cellular senescence through the regulation of chromatin organization and genome stability. bioRxiv. 2025\u5e743\u67084\u65e5<\/strong><\/p>\n\n\n\n

2023\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14, \u9ad8\u6c0f \u88d5\u8cb4, \u85e4\u4e95 \u9053\u5f66, \u9b8e\u6ca2 \u5927. \u518d\u751f\u533b\u7642\u30bb\u30df\u30ca\u30fc \u7d30\u80de\u306e\u8001\u5316\u3068\u82e5\u8fd4\u308a. \u65e5\u672c\u7f8e\u5bb9\u5916\u79d1\u5b66\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u6284\u9332\u96c6 111\u56de 296-297 2023\u5e745\u6708<\/p>\n\n\n\n

2022\u5e74<\/strong><\/p>\n\n\n\n

\u30fb Atsuki En, Shuo Takanashi, Rena Okazaki, Michihiko Fujii. A mutation in SLC30A9, a zinc transporter, causes an increased sensitivity to oxidative stress in the nematode Caenorhabditis elegans. Biochemical and Biophysical Research Communications 2022\u5e7410\u6708<\/strong><\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f \u88d5\u8cb4, \u5c71\u4e0a \u7fa9\u5df3, \u4e09\u6728 \u5065\u8f14, Hossain Mohammad Nazir, \u9b8e\u6fa4 \u5927, \u85e4\u4e95 \u9053\u5f66. \u30a2\u30de\u30e9\u30ad\u306e\u591a\u5f69\u306a\u6a5f\u80fd\u6027. \u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u7814\u7a76\u7dcf\u4f1a\u6284\u9332\u96c6 44\u56de 62-62 2022\u5e7410\u6708<\/p>\n\n\n\n

\u30fb Atsuki En, Kazuaki Watanabe, Dai Ayusawa, Michihiko Fujii<\/strong><\/strong>. The key role of a basic domain of histone H2B N-terminal tail in the action of 5-bromodeoxyuridine to induce cellular senescence. The FEBS Journal 2022\u5e747\u670826\u65e5<\/strong><\/strong><\/p>\n\n\n\n

\u30fb Md Ashikujjaman Ashik, Tasmia Islam, Michihiko Fujii, Md Morshedul Alam, Mohammad Nazir Hossain. Interaction pattern of aldose reductase with \u03b2-glucogallin: Active site exploration and multiple docking analyses. Informatics in Medicine Unlocked 30 100938-100938, 2022\u5e74<\/strong><\/strong><\/p>\n\n\n\n

2020\u5e74<\/strong><\/p>\n\n\n\n

\u30fbYamada N, Miki K, Yamaguchi Y, Takauji Y, Yamakami Y, Hossain MN, Ayusawa D, Fujii M. Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5\u03b1-reductase type II. Journal of cosmetic dermatology 19(11) 3083 – 3090 2020\u5e7411\u6708<\/strong><\/p>\n\n\n\n

\u30fbEn A, Takauji Y, Ayusawa D, Fujii M. The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). Experimental cell research 390(1) 111927 – 111927 2020\u5e745\u67081\u65e5 <\/strong><\/p>\n\n\n\n

\u30fbEn A, Takauji Y, Miki K, Ayusawa D, Fujii M. Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. FEBS Open Bio 2019\u5e7412\u670811\u65e5<\/strong><\/p>\n\n\n\n

2019\u5e74<\/strong><\/p>\n\n\n\n

\u30fbYamakami Y, Morino K, Takauji Y, Kasukabe R, Miki K, Hossain MN, Ayusawa D and Fujii M. Extract of Emblica officinalis enhances the growth of human keratinocytes in culture. J Integrative Medicine. 2019 Jan.<\/strong><\/p>\n\n\n\n

\u30fbArai R, En A, Takauji Y, Maki K, Miki K, Fujii M and Ayusawa D. Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. Mech Ageing Dev. 2019 Jan.<\/strong><\/p>\n\n\n\n

2018\u5e74<\/strong><\/p>\n\n\n\n

\u30fbAwaya A. Development of Many So-Called Autoimmune Diseases Including Various Vasculitis Syndromes May be Commonly Triggered by Pollen Exposure. Jacobs Journal of Allergy & Immunology. 2018 Dec.<\/strong><\/p>\n\n\n\n

\u30fbAsano G, Kubota S, Yamakami Y and Fujii M. IDENTIFICATION OF MANUBRIUM PIGMENTS IN TWO SPECIES OF Turritopsis MEDUSAE (CNIDARIA, HYDROZOA) IN JAPAN. Kurosio Biosphere. 2018, 14, 10-16<\/strong><\/p>\n\n\n\n

2017\u5e74<\/strong><\/p>\n\n\n\n

\u30fbTaoka M, Fujii M, Tsuchiya M, Uekita T, Ichimura T. A sensitive microbread-based organic media assisted method for proteomics sample preparation from dilute and denaturing solutions. ACS Appl Mater Interfaces. 2017, 9(49), 42661-42667.<\/strong><\/p>\n\n\n\n

\u30fbMahmud S, Haque S, Sarker D, Ayusawa D, Hossain MN. Disinfection of supplied drinking water by poly-herbal preparation. BJST. 2017 Dec<\/strong><\/p>\n\n\n\n

\u30fbTakauji Y, Kudo I, En A, Matsuo R, Hossain MN, Nakabayashi K, Miki K, Fujii M and Ayusawa D. GNG11 (G-protein \u0264 sununit 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells. Biochem Cell Biol. 2017 95:517-523<\/strong><\/p>\n\n\n\n

\u30fbMatsuo R, Mizobuchi S, Nakashima M, Miki K, Ayusawa D and Fujii M. Central roles of iron in the regulation of oxidative stress in the yeast Saccharomyces cerevisiae. Currt Genet. 2017, 63:895-907.<\/strong><\/p>\n\n\n\n

2016\u5e74<\/strong><\/p>\n\n\n\n

\u30fbAwaya A. Suppressive influence of seasonal influenza epidemic on Kawasaki disease onset. Jpn. J. Clin. Immunol. 2016, 6, 528-537.<\/strong><\/p>\n\n\n\n

\u30fbHossain MN, Azim DA, Ayusawa D, Sarkar AK and Ferdous T. Evaluation of poly herbal formulation in the management of Acne and Melasma. Int J Ayu Pharm Chem. 2016 Nov 16.<\/strong><\/p>\n\n\n\n

\u30fbTakauji Y, Morino K, Miki K, Hossain MN, Ayusawa D and Fujii M. Chyawanprash, a formulation of traditional Ayurvedic medicine, shows a protective effect on skin photoaging in hairless mice. J Integrative Medicine. 2016, 14,473-479.<\/strong><\/p>\n\n\n\n

\u30fbTakauji Y, Miki K, Mita J, Hossain MN, Yamauchi M, Kioi M, Ayusawa D and Fujii M. Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells. J Biosci. 2016, 41, 569-575.<\/strong><\/p>\n\n\n\n

\u30fbKudo I, Nozawa M, Miki K, Takauji Y, En A, Fujii M and Ayusawa D. Dual roles of ERK1\/2 in cellular senescence induced by excess thymidine in HeLa cells. Exp Cell Res. 2016, 346:216-223.<\/strong><\/p>\n\n\n\n

\u30fbTakauji Y, En A, Miki K, Ayusawa D and Fujii M. Combinatorial effects of continuous protein synthesis, ERK-signaling, and reactive oxygen species on induction of cellular senescence. Exp Cell Res. 2016, 345:239-46.<\/strong><\/p>\n\n\n\n

\u30fbRumi Arai, Atsuki En, Ryo Ukekawa, Kensuke Miki, Michihiko Fujii, Dai Ayusawa. Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells. Biochem Biophys Res Commun 2016, 473:1078-83.<\/strong><\/p>\n\n\n\n

\u30fbTakauji Y, Wada T, Takeda A, Kudoh I, Miki K, Fujii M and Ayusawa D. Restriction of protein synthesis abolishes senescence features at cellularand organismal levels. Sci Rep. 2016, 6:18722.<\/strong><\/p>\n\n\n\n

\u30fbYamakami Y, Yonekura R, Matsumoto Y, Takauji Y, Miki K, Fujii M and Ayusawa D. High concentrations of NaCl induce cell swelling leading to senescence in human cells. Mol Cell Biochem. 2016, 411:117-25.<\/strong><\/p>\n\n\n\n

2015\u5e74<\/strong><\/p>\n\n\n\n

\u30fbSattya Narayan Talukdar, Dai Ayusawa, Md. Rasel Al Mahmud, Mohammad Nazir Hossain. D4476, a cell-permeant inhibitor of CK1, potentiates the action of Bromodeoxyuridine in inducing senescence in HeLa cells. Biojournal of Science and Technology. 2015 jan 15<\/strong><\/p>\n\n\n\n

2014\u5e74<\/strong><\/p>\n\n\n\n

\u30fbYamakami Y, Miki K, Yonekura R, Kudo I, Fujii M, Ayusawa D. Molecular basis for premature senescence induced by surfactants in normal human cells. Biosci Biotechnol Biochem. 2014,78(12):2022-9.<\/strong><\/p>\n\n\n\n

\u30fbAwaya A, Nishimura C. A combination of cross correlation andtrend analyses reveals that Kawasaki disease is a pollen-induced delayed-typehyper-sensitivity disease. Int J Environ Res Public Health. 2014 Mar 4;11(3):2628-41.<\/strong><\/p>\n\n\n\n

2012\u5e74<\/strong><\/p>\n\n\n\n

\u30fbUeno S, Yasutake K, Tohyama D, Fujimori T, Ayusawa D, Fujii M. Systematic screen for genes involved in the regulation of oxidative stress in the nematode Caenorhabditis elegans. Biochem Biophys Res Commun. 2012,420(3):552-7.<\/strong><\/p>\n\n\n\n

\u30fbKobayashi Y, Lee SS, Arai R, Miki K, Fujii M, Ayusawa D. ERK1\/2 mediates unbalanced growth leading to senescence induced by excess thymidine in human cells.Biochem Biophys Res Commun. 2012,425(4):897-901.<\/strong><\/p>\n\n\n\n

\u30fbAkira Awaya and Koji Murayama. Positive correlation between Japanese cedar pollen numbers and the development of Kawasaki disease.The Open Allergy Journal, 2012, 5, 1-10<\/strong><\/p>\n\n\n\n

2011\u5e74<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Shikatani K, Ogura K, Goshima Y, Ayusawa D. Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans. Genes Cells. 2011,16(1):69-79.<\/strong><\/p>\n\n\n\n

\u30fbYamakami Y, Miki K, Endoh M, Yonekura R, Ukekawa R, Kobayashi Y, Fujii M, Ayusawa D. Sublethal doses of surfactants induce premature senescence in normal human skin cells. Biosci Biotechnol Biochem. 2011,75(7):1395-8.<\/strong><\/p>\n\n\n\n

\u30fbTakayama S, Fujii M, Nakagawa Y, Miki K, Ayusawa D. N-terminal short fragment of TUP1 confers resistance to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2011,411(1):25-31.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Yasuda K, Hartman PS, Ayusawa D, Ishii N. A mutation in a mitochondrial dehydrogenase\/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.Genes Cells. 2011,16(10):1022-34.<\/strong><\/p>\n\n\n\n

2010\u5e74<\/strong><\/p>\n\n\n\n

\u30fbFujii M,Miki K,Takayama S,Ayusawa D. Identification of genes that affect sensitivity to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Mol Genet Genomics. 2010,283(5):461-8.<\/strong><\/p>\n\n\n\n

\u30fbMiki K, Shimizu M, Fujii M, Takayama S, Hossain MN, Ayusawa D. 5-bromodeoxyuridine induces transcription of repressed genes with disruption of nucleosome positioning. FEBS J. 2010,277(21):4539-48.<\/strong><\/p>\n\n\n\n

2009\u5e74<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Adachi N, Shikatani K, Ayusawa D. [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode. Genes Cells. 2009 ,14(4):457-68.<\/strong><\/p>\n\n\n\n

\u30fbEndoh M, Kobayashi Y, Yamakami Y, Yonekura R, Fujii M, Ayusawa D. Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence. Biogerontology. 2009,10(2):213-21.<\/strong><\/p>\n\n\n\n

2008\u5e74<\/strong><\/p>\n\n\n\n

\u30fbKobayashi Y, Sakemura R, Kumagai A, Sumikawa E, Fujii M, Ayusawa D.Nuclear swelling occurs during premature senescence mediated by MAP kinases in nomal human fibroblasts. Biosci Biotechnol Biochem. 2008, 72(4): 1122-5.<\/strong><\/p>\n\n\n\n

\u30fbMiki K, Shimizu M, Fujii M, Hossain MN, Ayusawa D. 5-Bromouracil disrupts nucleosome positioning by inducing A-form-like DNA conformation in yeast cells. Biochem Biophys Res Commun. 2008, 368(3): 662-9.<\/strong><\/p>\n\n\n\n

\u30fbKurosawa A, Koyama H, Takayama S, Miki K, Ayusawa D, Fujii M, Iiizumi S, Adachi N. The requirement of Artemis in double strand break repair depends on the type of DNA damage. DNA Cell Biol. 2008, 27(1): 55-61.<\/strong><\/p>\n\n\n\n

2007\u5e74<\/strong><\/p>\n\n\n\n

\u30fbTakayama S, Fujii M, Kurosawa A, Adachi N, Ayusawa D. Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Curr Genet. 2007, 52(5-6): 203-11.<\/strong><\/p>\n\n\n\n

\u30fbArivazhagan P, Ayusawa D. Cardiolipin activates MAP kinases during premature senescence in normal human fibroblasts. Biogerontology. 2007, 8(6): 621-6.<\/strong><\/p>\n\n\n\n

\u30fbEndoh M, Miki K, Hossain MN, Fujii M, Ayusawa D. 5-Bromodeoxyuridine increases transient expression of ectopic genes in human cells. Biosci Biotechnol Biochem. 2007, 71(4):1098-102.<\/strong><\/p>\n\n\n\n

\u30fbHossain MN, Fujii M, Miki K, Endoh M, Ayusawa D. Downregulation of hnRNP C1\/C2 by siRNA sensitizes HeLa cells to various stresses. Mol Cell Biochem. 2007, 296(1-2): 151-7.<\/strong><\/p>\n\n\n\n

\u30fbUkekawa R, Miki K, Fujii M, Hirano H, Ayusawa D. Accumulation of multiple forms of lamin A with down-regulation of FACE-1suppresses growth in senescent human cells.Genes Cells. 2007, 12(3): 397-406.<\/strong><\/p>\n\n\n\n

2006\u5e74<\/strong><\/p>\n\n\n\n

\u30fbArivazhagan P, Ayusawa D, Panneerselvam C. Protective efficacy of alpha-lipoic acid on acetylcholinesterase activity in aged rat brain regions. Rejuvenation Res. 2006, 9 (2): 198-201.<\/strong><\/p>\n\n\n\n

\u30fbHossain MN, Sakemura R, Fujii M, Ayusawa D. G-protein gamma subunit GNG11 strongly regulates cellular senescence. Biochem Biophys Res Commun. 2006, 351(3): 645-50.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Kawai Y, Endoh M, Hossain MN, Nakabayashi K, Ayusawa D. Expression of RAB27B is up-regulated in senescent human cells. Mech Ageing Dev. 2006, 127(7): 639-42.<\/strong><\/p>\n\n\n\n

2005\u5e74<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Tanaka N, Miki K, Hossain MN, Endoh M, Ayusawa D. Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans. Biosci Biotechnol Biochem. 2005, 69(10):2015-8.<\/strong><\/p>\n\n\n\n

\u30fbSumikawa E, Matsumoto Y, Sakemura R, Fujii M, Ayusawa D. Prolonged unbalanced growth induces cellular senescence markers linked with mechano transduction in normal and tumor cells. Biochem Biophys Res Commun. 2005, 335(2): 558-65.<\/strong><\/p>\n\n\n\n

\u30fbMinagawa S, Nakabayashi K, Fujii M, Scherer SW, Ayusawa D. Early BrdU-responsive genes constitute a novel class of senescence-associated genes in human cells. Exp Cell Res. 2005, 304(2): 552-8.<\/strong><\/p>\n\n\n\n

2004\u5e74<\/strong><\/p>\n\n\n\n

\u30fbUkekawa R, Maegawa N, Mizutani E, Fujii M, Ayusawa D. Proteasome inhibitors induce changes in chromatin structure characteristic of senescent human fibroblasts. Biosci Biotechnol Biochem. 2004, 68(11): 2395-7.<\/strong><\/p>\n\n\n\n

\u30fbArivazhagan P, Mizutani E, Fujii M, Ayusawa D. Cardiolipin induces premature senescence in normal human fibroblasts. Biochem Biophys Res Commun. 2004, 323(3): 739-42.<\/strong><\/p>\n\n\n\n

\u30fbMinagawa S, Nakabayashi K, Fujii M, Scherer SW, Ayusawa D. Functional and chromosomal clustering of genes responsive to 5-bromodeoxyuridine in human cells. Exp Gerontol. 2004, 39(7): 1069-78.<\/strong><\/p>\n\n\n\n

\u30fbJoguchi A, Fujii M, Ayusawa D. Increased catalase activity in mouse cell mutants resistant to paraquat. Biogerontology. 2004, 5(3): 193-200.<\/strong><\/p>\n\n\n\n

\u30fbSatou W, Suzuki T, Noguchi T, Ogino H, Fujii M, Ayusawa D. AT-hook proteins stimulate induction of senescence markers triggered by 5-bromodeoxyuridine in mammalian cells. Exp Gerontol. 2004, 39(2): 173-9.<\/strong><\/p>\n\n\n\n

\u30fbSatou W, Tanimoto H, Ukekawa R, Fujii M, Ayusawa D. Amplification of nuclear aldolase A in mouse cell mutants resistant to Hoechst33342. Biochem Biophys Res Commun. 2004, 315(4): 845-9.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Matsumoto Y, Tanaka N, Miki K, Suzuki T, Ishii N, Ayusawa D. Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans. J Biol Chem. 2004, 279(19): 20277-82.<\/strong><\/p>\n\n\n\n

\u30fbAwaya A, Sahashi N. The etiology of Kawasaki disease: Does intense release of pollen induce pollinosis in constitutionally allergic adults, while constitutionally allergic infants develop Kawasaki disease? Biomedicine & Pharmacotherapy, 2004 Mar;58(2):136-40.<\/strong><\/p>\n\n\n\n

2003\u5e74<\/strong><\/p>\n\n\n\n

\u30fbAwaya A, Watanabe K, Kato S. Individuals exhibiting conspicuous nevi (lentigo\u3000simplex) are resistant to allergic rhinitis\/conjunctivitis (pollinosis), but those who do not show increased susceptibility to pollinosis. Microbiol Immunol. 2003;47(1):101-3.<\/strong><\/p>\n\n\n\n

2002\u5e74<\/strong><\/p>\n\n\n\n

\u30fbLettice LA, Horikoshi T, Heaney SJ, van Baren MJ, van der Linde HC,Breedveld GJ, Joosse M, Akarsu N, Oostra BA, Endo N, Shibata M, Suzuki M, Takahashi E, Shinka T, Nakahori Y, Ayusawa D, Nakabayashi K, Scherer SW, Heutink P, Hill RE, Noji S. Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc Natl Acad Sci U S A. 2002, 99:7548-53.<\/strong><\/p>\n\n\n\n

\u30fbOgino H, Satou W, Fujii M, Suzuki T, He Y, Michishita E, Ayusawa D. The human MYOD1 transgene is suppressed by 5-bromodeoxyuridine in mouse myoblasts. J Biochem (Tokyo). 2002, 132(6): 953-9.<\/strong><\/p>\n\n\n\n

\u30fbSuzuki T, Fujii M, Ayusawa D. Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts. Exp Gerontol. 2002, 37(8-9): 1005-14.<\/strong><\/p>\n\n\n\n

\u30fbMichishita E, Kurahashi T, Suzuki T, Fukuda M, Fujii M, Hirano H, Ayusawa D. Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells. Exp Gerontol. 2002, 37(7): 885-90.<\/strong><\/p>\n\n\n\n

\u30fbJoguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D. Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat. Biochem Biophys Res Commun. 2002, 293(1): 293-7.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Ito H, Hasegawa T, Suzuki T, Adachi N, Ayusawa D. 5-Bromo-2′-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2002, 66(4): 906-9.<\/strong><\/p>\n\n\n\n

\u30fbMichishita E, Matsumura N, Kurahashi T, Suzuki T, Ogino H, Fujii M, Ayusawa D. 5-Halogenated thymidine analogues induce a senescence-like phenomenon in HeLa cells. Biosci Biotechnol Biochem. 2002, 66(4): 877-9.<\/strong><\/p>\n\n\n\n

\u30fbSuzuki T, Michishita E, Ogino H, Fujii M, Ayusawa D. Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells. Exp Cell Res. 2002, 276(2): 174-84.<\/strong><\/p>\n\n\n\n

\u30fbOgino H, Fujii M, Satou W, Suzuki T, Michishita E, Ayusawa D. Binding of 5-bromouracil-containing S\/MAR DNA to the nuclear matrix. DNA Res. 2002, 9(1): 25-9.<\/strong><\/p>\n\n\n\n

2001\u5e74<\/strong><\/p>\n\n\n\n

\u30fbSuzuki T, Yaginuma M, Oishi T, Michishita E, Ogino H, Fujii M, Ayusawa D. 5-Bromodeoxyuridine suppresses position effect variegation of transgenes in HeLa cells. Exp Cell Res. 2001, 266(1): 53-63.<\/strong><\/p>\n\n\n\n

\u30fbSuzuki T, Minagawa S, Michishita E, Ogino H, Fujii M, Mitsui Y, Ayusawa D. Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells. Exp Gerontol. 2001, 36(3): 465-74.<\/strong><\/p>\n\n\n\n

\u30fbSado K, Ayusawa D, Enomoto A, Suganuma T, Oshimura M, Sato K, Koyama H. Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells. J Biol Chem. 2001 276:9742-8.<\/strong><\/p>\n\n\n\n

2000\u5e74<\/strong><\/p>\n\n\n\n

\u30fbIshiia H, Sasaki Y, Goshima Y, Kanai Y, Endou H, Ayusawa D, Ono H, Miyamae T, Misu Y. Involvement of rBAT in Na(+)-dependent and -independent transport of the neurotransmitter candidate L-DOPA in Xenopus laevis oocytes injected with rabbit small intestinal epithelium poly A(+) RNA. Biochim Biophys Acta. 2000 1466:61-70.<\/strong><\/p>\n\n\n\n

\u30fbFujiwara J, Fujii M, Shimoda M, Ayusawa D. Identification of the UV-responsive sequence in the human tissue plasminogenactivator gene. Biosci Biotechnol Biochem. 2000, 64(5):1084-7.<\/strong><\/p>\n\n\n\n

1999\u5e74<\/strong><\/p>\n\n\n\n

\u30fbMichishita E, Nakabayashi K, Suzuki T, Kaul SC, Ogino H, Fujii M, Mitsui Y, Ayusawa D. 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J Biochem (Tokyo). 1999, 126(6): 1052-9.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Joguchi A, Ogino H, Nakabayashi K, Ayusawa D. Dephosphorylation of specific proteins during induction of senescence in immortal human fibroblasts expressing thermolabile SV40 T antigen. Biosci Biotechnol Biochem. 1999, 63(6): 1116-8.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Ide A, Nakabayashi K, Joguchi A, Ogino H, Ayusawa D. The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 large T antigen. J Biochem (Tokyo). 1999, 125(3): 531-6.<\/strong><\/p>\n\n\n\n

1998\u5e74<\/strong><\/p>\n\n\n\n

\u30fbMichishita E, Nakabayashi K, Ogino H, Suzuki T, Fujii M, Ayusawa D. DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts. Biochem Biophys Res Commun. 1998, 253(3): 667-71.<\/strong><\/p>\n\n\n\n

\u30fbOgino H, Nakabayashi K, Michishita E, Scherer SW, Fujii M, Suzuki T, Ayusawa D. Clustering of human chromosome fragments on the mouse genome by chromosome-mediated gene transfer. DNA Res. 1998, 5(4) :247-50.<\/strong><\/p>\n\n\n\n

\u30fbIde A, Fujii M, Nakababashi K, Ayusawa D. Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein. Biosci Biotechnol Biochem. 1998, 62(7): 1458-60.<\/strong><\/p>\n\n\n\n

\u30fbIshii N, Fujii M, Hartman PS, Tsuda M, Yasuda K, Senoo-Matsuda N, Yanase S, Ayusawa D, Suzuki K. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature. 1998, 394(6694): 694-7.<\/strong><\/p>\n\n\n\n

\u30fbOgino H, Nakabayashi K, Suzuki M, Takahashi E, Fujii M, Suzuki T, Ayusawa D. Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity. Biochem Biophys Res Commun. 1998, 248(2): 223-7.<\/strong><\/p>\n\n\n\n

\u30fbFujii M, Ishii N, Joguchi A, Yasuda K, Ayusawa D. A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans. DNA Res. 1998, 5(1): 25-30.<\/strong><\/p>\n\n\n\n

1997\u5e74<\/strong><\/p>\n\n\n\n

Nakabayashi K, Ogata T, Fujii M, Tahara H, Ide T, Wadhwa R, Kaul SC, Mitsui Y, Ayusawa D. Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1. Exp Cell Res. 1997, 235(2): 345-53.<\/strong><\/p>\n\n\n\n

-\u8457\u66f8\u7b49-<\/strong><\/h3>\n\n\n\n

2013\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u4e09\u6728\u5065\u8f14\u3001Mohammad N Hossain\uff1a\u751f\u547d\u306e\u79d1\u5b66\u3000\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u3000\u30b5\u30f3\u30ac\u6587\u5eab<\/strong><\/p>\n\n\n\n

2009\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u2015\u30a4\u30f3\u30c95\u5343\u5e74\u306e\u667a\u6167\u304c\u4f1d\u3048\u308b\u4e0d\u8001\u9577\u5bff\u306e\u79d1\u5b66\u3000\u30b5\u30f3\u30ac<\/strong><\/p>\n\n\n\n

2007\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u4e0d\u8001\u9577\u5bff\u306e\u533b\u5b66\u300c\u8001\u5316\u306e\u30b5\u30a4\u30f3\u306f\u30a2\u30ab\u304c\u51fa\u306a\u304f\u306a\u308b\u3053\u3068\u300d\u75c5\u614b\u3092\u89e3\u6790\u3059\u308b\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u30011010\u300015\uff1a7-9\u30012007\u3000\u8349\u9686\u793e<\/strong><\/p>\n\n\n\n

2005\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u8acb\u5ddd\u4eae\uff1a\u75c5\u614b\u3092\u89e3\u6790\u3059\u308b\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3001\u3076\u3093\u305b\u304d2005\u300111\u3001600-606\u30012005<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u4e0d\u8001\u4e0d\u6b7b\u3001\u7d9c\u5408\u81e8\u5e8a\u300054\uff1a168-170, 2005<\/strong><\/p>\n\n\n\n

\u30fb\u7c9f\u5c4b\u662d\uff1a\u300c\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u5c0f\u5150\u306e\u307b\u304f\u308d\u306e\u6570\u306f\u3001\u5065\u5e38\u5150\u306b\u6bd4\u3079\u5c11\u306a\u3044\u300d\u3068\u3044\u3046\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u5831\u544a\u306b\u3064\u3044\u3066\uff0d\uff0d\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u514d\u75ab\u5b66\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u958b\u62d3\u304c\u6c42\u3081\u3089\u308c\u308b\uff0d\uff0d\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u514d\u75ab Vol.12, No.8, 2005, 1214\uff5e1217<\/strong><\/p>\n\n\n\n

2004\u5e74<\/strong><\/p>\n\n\n\n

\u30fbAyusawa, D: Role of the nuclear matrix in cellular senescence. \u300cNuclear Dynamics\u300d: Approaches from Molecular, Biochemical and Visual Biology (Nagata K and Takeyasu K eds.) 2004, Springer-Verlag Inc.<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u30af\u30ed\u30de\u30c1\u30f3\u3078\u306e\u4f5c\u7528\u3068\u7d30\u80de\u8001\u5316\u306e\u8a98\u5c0e\u6a5f\u69cb\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u8a8c\u300078\uff1a41-44\uff0c2004<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u4e0d\u8001\u4e0d\u6b7b\u3092\u6c42\u3081\u3066\u3001\u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u8ad6\u53e256\u5dfb\u7b2c3\u53f7\u3000\uff5039-43, 2004<\/strong><\/p>\n\n\n\n

\u30fb\u7c9f\u5c4b\u662d\uff1a\u82b1\u7c89\u60f9\u8d77(\u8a98\u5c0e)\u75be\u60a3\u306e\u3044\u304f\u3064\u3082\u306e\u5b58\u5728\u3092\u5b9f\u8a3c\u3059\u308b\u7814\u7a76\u306e\u7740\u624b\u306e\u6025\u52d9\uff0d\u300c\u5ddd\u5d0e\u75c5\u306etrigger\u306f\u3001\u82b1\u7c89\u3067\u3042\u308d\u3046\u300d\u3068\u3044\u3046\u77e5\u898b\u3092\u51fa\u767a\u70b9\u3068\u3057\u3066\uff0d\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u81e8\u5e8a24(5)\uff0c2004\uff0c376-379.<\/strong><\/p>\n\n\n\n

2003\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u5185\u6b63\u525b\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u306e\u5897\u6b96\u3068\u6210\u9577\u56e0\u5b50\u3001\u751f\u7269\u85ac\u79d1\u5b66\u5b9f\u9a13\u8b1b\u5ea7\u7b2c6\u5dfb\uff08\u4e95\u51fa\u5229\u61b2\u7de8\uff09\u3001p75-84, 2003\u3000\u5ee3\u5ddd\u66f8\u5e97<\/strong><\/p>\n\n\n\n

\u30fbAyusawa, D: Therapeutic induction of cellular senescence: Nuclear matrix in senescence. Ageing of cells In and Outside the Body (Kaul SC and Wadhwa R eds.) p239-255, 2003, Kluwer Academic Publishers<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u751f\u4f53\u6a5f\u80fd\u3068\u8001\u5316\u3001\u65e5\u672c\u98df\u54c1\u65b0\u7d20\u6750\u7814\u7a76\u4f1a\u8a8c\u30006:29-37, 2003<\/strong><\/p>\n\n\n\n

2002\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u75c5\u614b\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3001\u8ab2\u984c\u3068\u5c55\u671b\u3000\u73fe\u4ee3\u5316\u5b66\u5897\u520a 42:83-86, 2002<\/strong><\/p>\n\n\n\n

\u30fb\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30af\u30ed\u30de\u30c1\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u52d5\u3000\u73fe\u4ee3\u5316\u5b66\u5897\u520a 42:158-164, 2002<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u3000\u533b\u5b66\u306e\u3042\u3086\u307f 202:359-363, 2002<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u300c\u533b\u5b66\u5927\u8f9e\u5178\u300d\uff08\u4f0a\u85e4\u6b63\u7537\u3001\u4e95\u6751\u88d5\u592b\u3001\u9ad8\u4e45\u53f2\u9ebf\u7de8\u96c6\uff09\u533b\u5b66\u66f8\u9662\uff08\u5206\u62c5\u57f7\u7b46\uff092002<\/strong><\/p>\n\n\n\n

2001\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u8001\u5316\u3068\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u76ae\u819a\u79d1\u306e\u81e8\u5e8a\u300043:1261-1269, 2001<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u300c\u514d\u75ab\u5b66\u8f9e\u5178\u300d\uff08\u5927\u6ca2\u5229\u662d\u4ed6\u7de8\u96c6\uff09\u6771\u4eac\u5316\u5b66\u540c\u4eba\uff08\u5206\u62c5\u57f7\u7b46\uff092001<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\uff1a\u65e5\u7d4c\u7523\u696d\u65b0\u805e\u8a18\u4e8b\uff082001.7.16\uff09\u6d3b\u6027\u9178\u7d20\u8010\u6027\u3000\u7dda\u866b\u5909\u7570\u682a\u3068\u5bff\u547d<\/strong><\/p>\n\n\n\n

2000\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9234\u6728\u654f\u548c\uff1a\u7d30\u80de\u8001\u5316\u3092\u652f\u914d\u3059\u308b\u907a\u4f1d\u5b50\u3001\u5316\u5b66\u3068\u751f\u7269 38:224-229, 2000<\/strong><\/p>\n\n\n\n

-\u5b66\u4f1a\u767a\u8868-<\/strong><\/h3>\n\n\n\n

2019\u5e74<\/strong><\/p>\n\n\n\n

2018\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u771e\u6728\u5553\u4f51\u3001\u65b0\u4e95\u7559\u5b9f\u3001\u5713\u6566\u8cb4\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. Lamin B receptor (LBR)\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272. \u7b2c41\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u7530\u306a\u3064\u304d\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u30d2\u30c8\u7d30\u80de\u306e\u5897\u6b96\u3092\u8abf\u7bc0\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22. \u7b2c41\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u7af9\u672c\u5065\u592a\u90ce\u3001\u5713\u6566\u8cb4\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u30d2\u30c8SUSM-1\u7d30\u80de\u682a\u306b\u304a\u3051\u308b\u7d30\u80de\u4e0d\u6b7b\u5316\u6a5f\u69cb\u306e\u89e3\u6790. \u7b2c41\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u68a8\u6731\u592e\u3001\u9f4b\u85e4\u512a\u6a39\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u7dda\u866b C. elegans\u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790. \u7b2c41\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5713\u6566\u8cb4\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u85e4\u4e95\u9053\u5f66. \u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u3092\u7528\u3044\u305f\u7d30\u80de\u8001\u5316\u8a98\u5c0e\u6a5f\u69cb\u306e\u89e3\u6790. \u7b2c41\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f\u88d5\u8cb4\u3001\u897f\u672c\u66a2\u5c2d\u3001\u590f\u4e95\u771f\u8863\u5b50\u3001\u4e09\u6728\u5065\u8f14\u3001\u3000Mohammad N Hossain\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u7dda\u866b C. elegans\u3092\u7528\u3044\u305f\u8001\u5316\u9632\u6b62\u52b9\u679c\u3092\u6709\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22.\u3000\u7b2c40\u56de\u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u91d1\u6ca2\u7814\u7a76\u7dcf\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001Mohammad N Hossain\u3001\u7f8e\u99ac\u535a\u53f2\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927.\u3000\u81ea\u7136\u598a\u5a20\u529b\u3092\u9ad8\u3081\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u51e6\u65b9\u306e\u691c\u8a0e.\u3000\u7b2c40\u56de\u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u91d1\u6ca2\u7814\u7a76\u7dcf\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001Mohammad N Hossain\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u30a2\u30de\u30e9\u30ad\u306e\u7d30\u80de\u5897\u6b96\u4fc3\u9032\u56e0\u5b50\u306e\u540c\u5b9a.\u3000\u7b2c40\u56de\u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u91d1\u6ca2\u7814\u7a76\u7dcf\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u7530\u306a\u3064\u304d\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u304c\u3093\u7d30\u80de\u306b\u9ad8\u3044\u5897\u6b96\u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22.\u3000\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2018\u5e74\u5ea6\u5927\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u5c71\u7530\u306a\u3064\u304d\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u57f9\u5730\u4e2d\u30a2\u30df\u30ce\u9178\u91cf\u306f\u7d30\u80de\u8001\u5316\u306e\u8a98\u5c0e\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b.\u3000\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2018\u5e74\u5ea6\u5927\u4f1a\u3000<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u68a8\u6731\u592e\u3001\u9f4b\u85e4\u512a\u6a39\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u7dda\u866b C. elegans \u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u682a\u306e\u89e3\u6790.\u3000\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2018\u5e74\u5ea6\u5927\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5824\u674f\u5b50\u3001\u5713\u6566\u8cb4\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u51fa\u82bd\u9175\u6bcd Saccharomyces cerevisiae\u3000\u3092\u7528\u3044\u305f5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u660e.\u3000\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2018\u5e74\u5ea6\u5927\u4f1a<\/strong><\/p>\n\n\n\n

2017\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u5713\u6566\u8cb4\u3001\u65b0\u4e95\u7559\u5b9f\u3001\u85e4\u4e95\u9053\u5f66. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308blamin B receptor \u306e\u5f79\u5272. 2017\u5e74\u5ea6\u751f\u547d\u79d1\u5b66\u7cfb\u5b66\u4f1a\u5408\u540c\u5e74\u6b21\u5927\u4f1a\u3000\u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u5c71\u7530\u306a\u3064\u304d\u3001\u9b8e\u6fa4\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u57f9\u5730\u4e2d\u30a2\u30df\u30ce\u9178\u91cf\u306f\u7d30\u80de\u8001\u5316\u306e\u8a98\u5c0e\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b. 2017\u5e74\u5ea6\u751f\u547d\u79d1\u5b66\u7cfb\u5b66\u4f1a\u5408\u540c\u5e74\u6b21\u5927\u4f1a\u3000\u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001Mohammad N Hossain\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927. \u80b2\u6bdb\u52b9\u679c\u3092\u6709\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u690d\u7269\u306e\u63a2\u7d22. \u7b2c39\u56de\u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u7814\u7a76\u7dcf\u4f1a\uff08\u5171\u540c\u56fd\u969b\u4f1a\u8b702017\uff09 \u798f\u5ca1<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f\u88d5\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001Mohammad N Hossain\u3001\u5c71\u5185\u6b63\u525b\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u653e\u5c04\u7dda\u9632\u5fa1\u52b9\u679c. \u7b2c39\u56de\u65e5\u672c\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u5b66\u4f1a\u7814\u7a76\u7dcf\u4f1a\uff08\u5171\u540c\u56fd\u969b\u4f1a\u8b702017\uff09 \u798f\u5ca1<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u5713\u6566\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u5236\u9650\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790. \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2017\u5e74\u5ea6\u5927\u4f1a\u3000\u4eac\u90fd<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u9ad9\u6c0f\u88d5\u8cb4\u3001Mohammad N Hossain\u3001\u5c71\u5185\u6b63\u525b\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u690d\u7269\u306e\u653e\u5c04\u7dda\u9632\u5fa1\u52b9\u679c. \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2017\u5e74\u5ea6\u5927\u4f1a\u3000\u4eac\u90fd<\/strong><\/p>\n\n\n\n

2016\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u5713\u6566\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u5236\u9650\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790. \u7b2c39\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u5713\u6566\u8cb4\u3001\u65b0\u4e95\u7559\u5b9f\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f79\u5272. \u7b2c39\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u677e\u5c3e\u907c\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u3092\u7528\u3044\u305f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u660e. \u7b2c39\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u897f\u672c\u66a2\u5c2d\u3001\u6b66\u7530\u3042\u3059\u304b\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001Mohammad N Hossain\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\u3001\u85e4\u4e95\u9053\u5f66. \u7dda\u866b\u306e\u5bff\u547d\u3092\u5ef6\u9577\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22.\u3000\u7b2c39\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u65b0\u4e95\u7559\u5b9f\u3001\u5713\u6566\u8cb4\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f79\u5272. \u7b2c39\u56de\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\u5927\u4f1a\u30002016\u5e745\u6708\u3000\u4f0a\u52e2\u539f<\/strong><\/p>\n\n\n\n

\u30fb\u5713\u6566\u8cb4\u3001\u65b0\u4e95\u7559\u5b9f\u3001\u85e4\u4e95\u9053\u5f66. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u819c\u69cb\u9020\u306e\u5909\u5316. \u7b2c39\u56de\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\u5927\u4f1a\u30002016\u5e745\u6708\u3000\u4f0a\u52e2\u539f<\/strong><\/p>\n\n\n\n

2015\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14,\u3001\u7c73\u5009\u4f51\u9999\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001Mohammad N Hossain\u3001\u9b8e\u6ca2\u3000\u5927,\u3001\u85e4\u4e95\u9053\u5f66.\u3000\u80b2\u6bdb\u52b9\u679c\u3092\u6709\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22. \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2015\u5e74\u5ea6\u5927\u4f1a \u5ca1\u5c71<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u548c\u7530\u5353\u5df3\u3001\u5de5\u85e4\u751f\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6fa4 \u5927. \u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u5236\u9650\u306b\u3088\u308b\u30d2\u30c8\u7d30\u80de\u8001\u5316\u306e\u6291\u5236.\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2015\u5e74\u5ea6\u5927\u4f1a \u5ca1\u5c71<\/strong><\/p>\n\n\n\n

\u30fb\u68ee\u91ce\u9999\u5b50\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001Mohammad N Hossain\u3001\u9b8e\u6ca2 \u5927\u3001\u85e4\u4e95 \u9053\u5f66. \u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u30a2\u30de\u30e9\u30ad(Emblica officinalis)\u542b\u6709\u6210\u5206\u306e\u89e3\u6790. \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2015\u5e74\u5ea6\u5927\u4f1a \u5ca1\u5c71<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u548c\u7530\u5353\u5df3\u3001\u6b66\u7530\u3042\u3059\u304b\u3001\u5de5\u85e4\u751f\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6fa4 \u5927. \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7de9\u3084\u304b\u306a\u5408\u6210\u5236\u9650\u306f\u8001\u5316\u3092\u6291\u5236\u3059\u308b.\u3000\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\u7b2c38\u56de\u5927\u4f1a\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fbYuki Takauji, Takumi Wada, Asuka Takeda, Ikuru Kudo, Kensuke Miki, Michihiko Fujii and Dai Ayusawa. MILD RESTRICTION OF PROTEIN SYNTHESIS ABOLISHES ALL ASPECTS OF SENESCENT PHENOTYPES AT CELLULAR AND INDIVIDUAL LEVELS. 10th IAGG Asia\/Oceania Congress\u3000Chiang Mai, Thailand<\/strong><\/p>\n\n\n\n

\u30fbYuki Takauji, Takumi Wada, Asuka Takeda, Ikuru Kudo, Kensuke Miki, Michihiko Fujii and Dai Ayusawa. Restriction of protein synthesis abolishes senescence features at cellular and organismal levels. \u7b2c20\u56de\u9759\u5ca1\u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u65e9\u5ddd \u6e05\u3001\u65e9\u5ddd \u9756\u5f66\u3001\u9b8e\u6fa4 \u5927\u3001\u85e4\u4e95 \u9053\u5f66. \u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6cd5\u3092\u7528\u3044\u305f\u69d8\u3005\u306a\u751f\u7269\u7a2e\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165. BMB2015 \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u677e\u5c3e \u907c\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001\u9b8e\u6fa4 \u5927\u3001\u85e4\u4e95 \u9053\u5f66. \u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u3092\u7528\u3044\u305f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u6790. BMB2015 \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u5713 \u6566\u8cb4\u3001\u65b0\u4e95 \u7559\u5b9f\u3001\u8acb\u5ddd \u4eae\u3001\u4e09\u6728 \u5065\u8f14\u3001\u9b8e\u6fa4 \u5927\u3001\u85e4\u4e95 \u9053\u5f66. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u819c\u69cb\u9020\u306e\u5909\u5316. BMB2015 \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f \u88d5\u8cb4\u3001\u548c\u7530 \u5353\u5df3\u3001\u6b66\u7530 \u3042\u3059\u304b\u3001\u5de5\u85e4 \u751f\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6fa4 \u5927. \u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u5236\u9650\u306f\u8001\u5316\u3092\u6291\u5236\u3059\u308b. BMB2015 \u795e\u6238<\/strong><\/p>\n\n\n\n

2014\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u672b\u677e\u4f51\u7406\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u8001\u5316\u5fdc\u7b54\u907a\u4f1d\u5b50\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u306e\u5909\u5316” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f\u88d5\u8cb4\u3001\u68ee\u91ce\u9999\u5b50\u3001\u4e09\u6728\u5065\u8f14\u3001\u5c71\u5185\u6b63\u525b\u3001Hossain Mohammad N\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “DNA\u640d\u50b7\u306b\u5bfe\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u9632\u5fa1\u52b9\u679c” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u6b66\u7530\u3042\u3059\u304b\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u7dda\u866b\u306e\u8102\u80aa\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009\u4f51\u9999\u3001Hossain Mohammad N\u3001\u4e09\u6728\u5065\u8f14\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u30d2\u30c8\u6bdb\u4e73\u982d\u7d30\u80de\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u3078\u306e\u52b9\u679c” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u5341\u6587\u5b57\u6d69\u7f8e\u3001\u4e09\u6728\u5065\u8f14\u3001Hossain Mohammad N\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a\u7fa9\u5df3\u3001\u65e9\u5ddd\u6e05\u3001\u65e9\u5ddd\u9756\u5f66\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6cd5\u306b\u3088\u308b\u69d8\u3005\u306a\u751f\u7269\u7a2e\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a. (20140327-20140330). \u6771\u4eac<\/strong><\/p>\n\n\n\n

\u30fb\u9ad9\u6c0f\u88d5\u8cb4\u3001\u548c\u7530\u5353\u5df3\u3001\u5de5\u85e4\u751f\u3001\u65b0\u4e95\u7559\u5b9f\u3001\u5713\u6566\u8cb4\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927. \u9ad8\u5206\u5b50\u5408\u6210\u4e0d\u5747\u8861\u306e\u662f\u6b63\u306b\u3088\u308b\u30d2\u30c8\u7d30\u80de\u8001\u5316\u306e\u6291\u5236.\u3000\u7b2c37\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a.\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u65b0\u4e95\u7559\u5b9f\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u6838\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f79\u5272. \u7b2c37\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a.\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4\u751f\u3001\u91ce\u6ca2\u611b\u5b9f\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927. \u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bMAP\u30ad\u30ca\u30fc\u30bc\u304a\u3088\u3073\u7d30\u80de\u5468\u671f\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u6a5f\u69cb\u306e\u5f79\u5272. \u7b2c37\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a.\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u672b\u677e\u4f51\u7406\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927:5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3067\u8a98\u5c0e\u3055\u308c\u305f\u30d2\u30c8\u8001\u5316\u7d30\u80de\u306b\u304a\u3051\u308b\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u5909\u5316\u306e\u89e3\u6790. \u7b2c37\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a.\u3000\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

2013\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u6e96\u81f4\u6b7b\u91cf\u306e\u754c\u9762\u6d3b\u6027\u5264\u306b\u3088\u308b\u30d2\u30c8\u6b63\u5e38\u7d30\u80de\u306e\u672a\u6210\u719f\u8001\u5316\u306e\u8a98\u5c0e\u6a5f\u69cb” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u7c95\u8c37\u3000\u88d5\u6a39\u3001Mohammad N HOSSAIN\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4 \u751f\u3001\u4f0a\u85e4 \u967d\u5e73\u3001\u53e4\u8cc0 \u614e\u592a\u90ce\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “G\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u65b0\u4e95 \u7559\u5b9f\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u7d30\u80de\u8001\u5316\u306b\u4f34\u3046\u6838\u5185\u53ca\u3073\u6838\u819c\u69cb\u9020\u306e\u5909\u5316” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0\uff08\u5bae\u57ce\u770c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6749\u672c \u91cf\u5e73\u3001\u91ce\u6ca2\u3000\u611b\u7f8e\u3001\u7c73\u5009\u3000\u9686\u9020\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u30ad\u30ca\u30fc\u30bc\uff08Chk1, 2\uff09\u306e\u904e\u5270\u30c1\u30df\u30b8\u30f3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u8a98\u5c0e\u306b\u304a\u3051\u308b\u5f79\u5272” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u548c\u7530\u3000\u5353\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u7d30\u80de\u8001\u5316\u306e\u4e0d\u5747\u8861\u5897\u6b96\u30e2\u30c7\u30eb\u306e\u691c\u8a3c” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0\uff08\u5bae\u57ce\u770c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f\u3000\u88d5\u8cb4\u3001\u5c3e\u5d0e\u3000\u6d0b\u5b50\u3001\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u5185\u3000\u6b63\u525b\u3001Mohammad Nazir Hossain\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u653e\u5c04\u7dda\u9632\u8b77\u52b9\u679c” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009\u3000\u4f51\u9999\u3001\u5c71\u53e3 \u8449\u5b50\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: “\u30d2\u30c8\u6bdb\u4e73\u982d\u7d30\u80de\u306b\u304a\u3051\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u751f\u7406\u4f5c\u7528” \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2013\u5e74\u5ea6\u5927\u4f1a. \u4ed9\u53f0<\/strong><\/p>\n\n\n\n

\u30fb\u548c\u7530\u5353\u5df1\u3001\u9ad8\u6c0f\u88d5\u8cb4\u3001\u5c71\u4e0a\u7fa9\u5df3\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “\u7d30\u80de\u8001\u5316\u3092\u5c0e\u304f\u4e0d\u5747\u8861\u5897\u6b96\u306e\u662f\u6b63” \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20131203-20131206). \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u65b0\u4e95\u7559\u5b9f\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6fa4\u5927: “\u7d30\u80de\u8001\u5316\u306b\u4f34\u3046\u6838\u5185\u53ca\u3073\u6838\u819c\u69cb\u9020\u306e\u5909\u5316” \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20131203-20131206). \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4\u751f\u3001\u4f0a\u85e4\u967d\u5e73\u3001\u53e4\u8cc0\u614e\u592a\u90ce\u3001Hossain Mohammad N\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “G\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272” \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20131203-20131206). \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6c0f\u88d5\u8cb4\u3001\u68ee\u91ce\u9999\u5b50\u3001\u4e09\u6728\u5065\u8f14\u3001\u5c71\u5185\u6b63\u525b\u3001Hossain Mohammad N\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6fa4\u5927: “\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306eDNA\u640d\u50b7\u9632\u8b77\u4f5c\u7528” \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20131203-20131206). \u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a\u7fa9\u5df3\u3001\u65e9\u5ddd\u6e05\u3001\u65e9\u5ddd\u9756\u5f66\u3001\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927: “NEPA21\u3092\u7528\u3044\u305f\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u306b\u3088\u308b\u7d30\u80de\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165” \u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20131203-20131206). \u795e\u6238<\/strong><\/p>\n\n\n\n

2012\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u53e3 \u8449\u5b50\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30d2\u30c8\u6bdb\u4e73\u982d\u7d30\u80de\u306b\u304a\u3051\u308b\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u751f\u7406\u4f5c\u7528. \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2012\u5e74\u5ea6\u5927\u4f1a\u3000\u4eac\u90fd<\/strong><\/p>\n\n\n\n

\u30fb\u65b0\u4e95 \u7559\u5b9f\u3001\u8c37\u8107 \u6b69\u7f8e\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30d2\u30c8\u8001\u5316\u7d30\u80de\u306b\u304a\u3051\u308b\u6838\u5185\u69cb\u9020\u306e\u5909\u5316.\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2012\u5e74\u5ea6\u5927\u4f1a\u3000\u4eac\u90fd<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u4e09\u7530 \u5145\u771f\u3001MOHAMMAD N Hosasin\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u52b9\u679c\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002012\u5e74\u5ea6\u5927\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a \u7fa9\u5df3\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u6e96\u81f4\u6b7b\u91cf\u306e\u754c\u9762\u6d3b\u6027\u5264\u306b\u3088\u308b\u30d2\u30c8\u6b63\u5e38\u7d30\u80de\u306e\u672a\u6210\u719f\u8001\u5316\u306e\u8a98\u5c0e\u6a5f\u69cb\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002012\u5e74\u5ea6\u5927\u4f1a<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4\u3000\u751f\u3001\u4f0a\u85e4\u3000\u967d\u5e73\u3001\u53e4\u8cc0\u3000\u614e\u592a\u90ce\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1aG\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002012\u5e74\u5ea6\u5927\u4f1a \u4eac\u90fd<\/strong><\/p>\n\n\n\n

2011\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u53e3 \u8449\u5b50\u3001MOHAMMAD N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u8001\u5316\u306b\u4f34\u30465\u03b1R1\u306e\u767a\u73fe\u91cf\u306e\u5909\u5316\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u672c \u88d5\u4ecb\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u3092\u7528\u3044\u305f\u8001\u5ec3\u7269\u969c\u5bb3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u306e\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6839\u672c \u82f1\u6bd4\u53e4\u3001\u4e09\u7530 \u5145\u771f\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001MOHAMMAD N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30ac\u30f3\u7d30\u80de\u306b\u7279\u7570\u7684\u306a\u5897\u6b96\u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u6709\u52b9\u6210\u5206\u306e\u540c\u5b9a\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u7530 \u5145\u771f\u3001\u6839\u672c \u82f1\u6bd4\u53e4\u3001\u5c71\u53e3 \u8449\u5b50\u3001\u4e09\u6728 \u5065\u8f14\u3001MOHAMMAD N Hosasin\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u52b9\u679c\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u672c \u7950\u4ecb\u3001\u65e9\u5ddd \u6e05\u3001\u65e9\u5ddd \u9756\u5f66\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u3092\u7528\u3044\u305f\u63a5\u7740\u7d30\u80de\u3078\u306ein situ\u907a\u4f1d\u5b50\u5c0e\u5165\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4 \u751f\u3001\u4f0a\u85e4 \u967d\u5e73\u3001\u53e4\u8cc0 \u614e\u592a\u90ce\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1aG\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a \u7fa9\u5df3\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u6e96\u81f4\u6b7b\u91cf\u306e\u754c\u9762\u6d3b\u6027\u5264\u306b\u3088\u308b\u30d2\u30c8\u6b63\u5e38\u7d30\u80de\u306e\u672a\u6210\u719f\u8001\u5316\u306e\u8a98\u5c0e\u6a5f\u69cb\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009 \u9686\u9020\u3001\u677e\u672c \u7950\u5b50\u3001\u5c0f\u6797 \u88d5\u4ecb\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u9ad8\u6fc3\u5ea6\u5869\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u306b\u3088\u308b\u7d30\u80de\u306e\u8001\u5316\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u91ce\u6ca2 \u611b\u5b9f\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bp21\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002011\u5e74\u5ea6\u5927\u4f1a\u3000\uff082011\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6e9d\u6e15 \u7fd4\u543e\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927: \u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u3092\u7528\u3044\u305f\u6d3b\u6027\u9178\u7d20\u62b5\u6297\u6027\u907a\u4f1d\u5b50\u306e\u5358\u96e2\u3068\u89e3\u6790.\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20111214). \u30d1\u30b7\u30d5\u30a3\u30b3\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u5ddd\u53e3 \u7adc\u3001\u4e2d\u5ddd \u512a\u3001\u85e4\u4e95 \u9053\u5f66\u3001 \u9b8e\u6ca2 \u5927: \u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u306b\u304a\u3051\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u6790.\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20111214). \u30d1\u30b7\u30d5\u30a3\u30b3\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u672c \u7950\u4ecb\u3001\u65e9\u5ddd \u6e05\u3001\u65e9\u5ddd \u9756\u5f66\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u3092\u7528\u3044\u305f\u63a5\u7740\u7d30\u80de\u3078\u306ein situ\u907a\u4f1d\u5b50\u5c0e\u5165.\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a. (20111214). \u30d1\u30b7\u30d5\u30a3\u30b3\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

2010\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u4e2d\u5ddd \u512a\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u51fa\u82bd\u9175\u6bcd Saccharomyces cerevisiae \u306b\u304a\u3051\u308b5\u2212\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a \u7fa9\u5df3\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u754c\u9762\u6d3b\u6027\u5264\u306e\u7d30\u80de\u6bd2\u6027\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6749\u672c \u91cf\u5e73\u3001\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001Mohammad\u3000N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce1\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u30a2\u30de\u30e9\u30ad\uff08Emblica officinalis\uff09\u542b\u6709\u6210\u5206\u306e\u540c\u5b9a\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u52dd\u53c8 \u4e09\u6620\u5b50\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6a5f\u80fd\u3078\u5f71\u97ff\u3092\u53ca\u307c\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6839\u672c \u82f1\u6bd4\u53e4\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30ac\u30f3\u7d30\u80de\u306b\u7279\u7570\u7684\u306a\u5897\u6b96\u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u690d\u7269\u306e\u63a2\u7d22\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009 \u9686\u9020\u3001\u677e\u672c \u7950\u5b50\u3001\u5c0f\u6797 \u88d5\u4ecb\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u9ad8\u6fc3\u5ea6\u306e\u5869\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u306b\u3088\u308b\u7d30\u80de\u306e\u8001\u5316\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4 \u751f\u3001\u4f0a\u85e4 \u967d\u5e73\u3001\u53e4\u8cc0 \u614e\u592a\u90ce\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1aG\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c0f\u6797 \u88d5\u4ecb\u3001\u856d \u6dd1\u9e97\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bMAPK\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u672c \u88d5\u4ecb\u3001\u6f81\u8c37 \u5927\u8f14\u3001\u4e09\u6728 \u5065\u8f14\u3001\u65e9\u5ddd \u9756\u5f661\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u306e\u6700\u9069\u5316\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95 \u9053\u5f66\u3001\u9e7f\u8c37 \u4e00\u6a39\u3001\u9b8e\u6ca2 \u5927\uff1a\u7dda\u866bC. elegans\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u9ad8\u611f\u53d7\u6027\u5909\u7570\u4f53oxy-4\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002010\u5e74\u5ea6\u5927\u4f1a\u3000\uff082010\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u5c71\u672c \u7950\u4ecb\u3001\u65e9\u5ddd \u6e05\u3001\u65e9\u5ddd \u9756\u5f66\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u96fb\u6c17\u30d1\u30eb\u30b9\u6cd5\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u5c0e\u5165\u52b9\u7387\u306e\u6700\u9069\u5316\u3001BMB2010\uff082010\u5e7412\u6708\uff1a\u795e\u6238\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e0a\u91ce\u5cfb\u4ecb\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u7dda\u866b\uff08Caenorhabditis elegans\uff09\u306b\u304a\u3051\u308b\u9ad8\u6fc3\u5ea6\u9178\u7d20\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u3001BMB2010\uff082010\u5e7412\u6708\uff1a\u795e\u6238<\/strong><\/p>\n\n\n\n

\u30fb\u5de5\u85e4 \u751f\u3001\u4f0a\u85e4 \u967d\u5e73\u3001\u53e4\u8cc0 \u614e\u592a\u90ce\u3001Mohammad N Hossain\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1aG\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3001BMB2010\uff082010\u5e7412\u6708\uff1a\u795e\u6238)<\/strong><\/p>\n\n\n\n

2009\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9e7f\u8c37 \u4e00\u6a39\u3001\u85e4\u68ee \u529b\u3001\u5b89\u6b66 \u8cb4\u4e00\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u7dda\u866b Caenorhabditis elegans \u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e2d\u5ddd \u512a\u3001\u4e09\u6728 \u5065\u8f14\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u51fa\u82bd\u9175\u6bcd Saccharomyces cerevisiae \u306b\u304a\u3051\u308b5\uff0d\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u53e4\u8cc0 \u614e\u592a\u90ce\u3001Mohammad N HOSSAIN\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1aG\u30bf\u30f3\u30d1\u30af\u8cea\u03b3\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8GNG11\u306e\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009 \u9686\u9020\u3001\u677e\u672c \u7950\u5b50\u3001\u5c0f\u6797 \u88d5\u4ecb\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u9ad8\u6fc3\u5ea6\u98df\u5869\u306b\u3088\u308b\u7d30\u80de\u306e\u8001\u5316\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u98ef\u585a \u6643\u5f66\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001\u4e09\u6728 \u5065\u8f14\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u6717\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30ac\u30f3\u7d30\u80de\u306b\u7279\u7570\u7684\u306a\u5897\u6b96\u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728 \u5065\u8f14\u3001\u7fbd\u91ce \u535a\u4e4b\u3001\u5927\u5ddd \u88d5\u7f8e\u3001\u5c71\u4e0a \u7fa9\u5df3\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30d2\u30c8\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306b\u304a\u3051\u308b\u30a4\u30f3\u30c9\u30b9\u30b0\u30ea\u306e\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a \u7fa9\u5df3\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u754c\u9762\u6d3b\u6027\u5264\u306e\u7d30\u80de\u6bd2\u6027\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u856d \u6dd1\u9e97\u3001\u5c0f\u6797 \u88d5\u4ecb\u3001\u4f0a\u85e4 \u967d\u5e73\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bMAP\u30ad\u30ca\u30fc\u30bc\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u52dd\u53c8 \u4e09\u6620\u5b50\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306e\u63a2\u7d22\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6c38\u91ce \u745b\u5b50\u3001\u4f0a\u85e4 \u967d\u5e73\u3001Mohammad N Hossain\u3001\u5c71\u4e0b \u5f8b\u90ce\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u6bdb\u7403\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u6a5f\u5e8f\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002009\u5e74\u5ea6\u5927\u4f1a\u3000\uff082009\u5e743\u6708\uff1a\u798f\u5ca1\uff09<\/strong><\/p>\n\n\n\n

2008\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9ce5\u5c71\u6566\u3001\u5927\u5ddd\u88d5\u7f8e\u3001\u6c38\u91ce\u745b\u5b50\u3001Hossain, Mohammad N\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30cf\u30fc\u30d6\u3092\u7528\u3044\u305f\u30d2\u30c8\u76ae\u819a\u7d30\u80de\u306e\u8001\u5316\u9632\u6b62\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u8c37\u5b5d\u4e8c\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u6881\u512a\u9999\u3001Mohammad N, HOSSAIN\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u306eI\u578b\u30d7\u30ed\u30b3\u30e9\u30fc\u30b2\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u5c71\u613c\u4e00\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u51fa\u82bd\u9175\u6bcd Saccharomyces cerevisiae \u306b\u304a\u3051\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u5316\u6a5f\u69cb\u306e\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u6e05\u6c34\u5149\u5f18\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u5f62\u6210\u306e\u4e0d\u5b89\u5b9a\u5316\u6a5f\u69cb\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c71\u4e0a\u7fa9\u5df3\u3001\u611b\u77e5\u6cf0\u6210\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u65b0\u898f\u7d30\u80de\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7c73\u5009\u9686\u9020\u3001\u677e\u672c\u7950\u5b50\u3001\u5c0f\u6797\u88d5\u4ecb\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u9ad8\u6fc3\u5ea6NaC\uff4c\u306b\u3088\u308b\u7d30\u80de\u306e\u8001\u5316\u8a98\u5c0e\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u5b89\u6b66\u8cb4\u4e00\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002008\u5e74\u5ea6\u5927\u4f1a\uff082008\u5e743\u6708\uff1a\u540d\u53e4\u5c4b\uff09<\/strong><\/p>\n\n\n\n

2007\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u7c95\u58c1\u9686\u4e00\u90ce\u3001Mohammad, Nazir Hossain\u3001\u7c73\u5009\u9686\u9020\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u8868\u76ae\u89d2\u5316\u7d30\u80de\u306e\u5897\u6b96\u4fc3\u9032\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002007\u5e74\u5ea6\u5927\u4f1a\uff082007\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u6881\u512a\u9999\u3001\u9ce5\u5c71\u6566\u3001Mohammad, Nazir Hossain\u3001\u5c71\u4e0b\u5f8b\u90ce\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30a2\u30fc\u30e6\u30eb\u30f4\u30a7\u30fc\u30c0\u30cf\u30fc\u30d6\u306b\u3088\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u969c\u5bb3\u56de\u5fa9\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002007\u5e74\u5ea6\u5927\u4f1a\uff082007\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u6e05\u6c34\u5149\u5f18\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u3078\u306e\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2007\u5e74\u5ea6\u5927\u4f1a\uff082007\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u5c71\u613c\u4e00\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u306b\u304a\u3051\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2007\u5e74\u5ea6\u5927\u4f1a\uff082007\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5c0f\u6797\u88d5\u4ecb\u3001\u718a\u8c37\u6e29\u5b50\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bMAPK\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2007\u5e74\u5ea6\u5927\u4f1a\uff082007\u5e743\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

2006\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9060\u85e4\u58ee\u6717\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30d2\u30c8pregnancy-specific beta 1-glycoprotein(PSG)\u907a\u4f1d\u5b50\u7fa4\u306e\u6a5f\u80fd\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002006\u5e74\u5ea6\u5927\u4f1a\uff082006\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u8acb\u5ddd\u4eae\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30e9\u30df\u30f3\u53ca\u3073\u305d\u306e\u524d\u99c6\u4f53\u84c4\u7a4d\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2006\u5e74\u5ea6\u5927\u4f1a\uff082006\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u6e05\u6c34\u5149\u5f18\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u3078\u306e\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2006\u5e74\u5ea6\u5927\u4f1a\uff082006\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u5c71\u613c\u4e00\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u306b\u304a\u3051\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2006\u5e74\u5ea6\u5927\u4f1a\uff082006\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u9060\u5c71\u5927\u4ecb\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u306e\u30d1\u30e9\u30b3\u30fc\u30c8\u8010\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2006\u5e74\u5ea6\u5927\u4f1a\uff082006\u5e743\u6708\uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

2005\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u8acb\u5ddd\u4eae\u3001\u85e4\u4e95\u9053\u5f66\u3001\u5e73\u91ce\u4e45\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30e9\u30df\u30f3\u524d\u99c6\u4f53\u84c4\u7a4d\u306e\u5f79\u5272\u3001\u7b2c\uff15\u56de\u7d30\u80de\u6838\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u7814\u7a76\u4f1a\uff082005\u5e74\uff15\u6708\uff1a\u7bb1\u6839\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u6e05\u6c34\u5149\u5f18\u3001\u9b8e\u6ca2\u5927\uff1a5\u2212\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u3078\u306e\u4f5c\u7528\u3001\u7b2c\uff15\u56de\u7d30\u80de\u6838\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u7814\u7a76\u4f1a\uff082005\u5e74\uff15\u6708\uff1a\u7bb1\u6839\uff09<\/strong><\/p>\n\n\n\n

\u30fbNazir Hossain Mohammad, Michihiko Fujii, Dai Ayusawa : Role of hnRNPCI\/C2 in \uff43ellular senescence like phenomenon\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u5c71\u613c\u4e00\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u51fa\u82bd\u9175\u6bcdSaccharomycescerevisiae \u306b\u304a\u3051\u308b\uff15-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9060\u85e4\u58ee\u6717\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30d2\u30c8pregnancy-specific beta 1-glycoprotein(PSG)\u907a\u4f1d\u5b50\u7fa4\u306e\u6a5f\u80fd\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u8acb\u5ddd\u4eae\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u30e9\u30df\u30f3\u524d\u99c6\u4f53\u84c4\u7a4d\u306e\u5f79\u5272\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4e09\u6728\u5065\u8f14\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\uff15\u2212\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u69cb\u9020\u3078\u306e\u4f5c\u7528\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95 \u9053\u5f66\u3001\u4e09\u6728 \u5065\u8f14\u3001\u9b8e\u6ca2 \u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002005\u5e74\u5ea6\u5927\u4f1a\uff082005\u5e743\u6708\uff1a\u672d\u5e4c\uff09<\/strong><\/p>\n\n\n\n

2004\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u4e09\u6728\u5065\u8f14\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9b8e\u6ca2\u5927\uff1a Characterization of paraquat-resistant mutants in nematode Caenorhabditis elegans.\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\uff082004\u5e746\u6708\uff1a\u6771\u4eac\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u8acb\u5ddd\u4eae\u3001\u85e4\u4e95\u9053\u5f66\u3001\u5ddd\u5d0e\u535a\u53f2\u3001\u5e73\u91ce\u4e45\u3001\u9b8e\u6ca2\u5927\uff1aBrdU\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u306e\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7686\u5ddd\u5409\u3001\u6f84\u5ddd\u7d75\u7f8e\u3001\u4e2d\u6797\u4e00\u5f66\u3001\u85e4\u4e95\u9053\u5f66\u3001Scherer SW\u3001\u9b8e\u6ca2\u5927\uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u8001\u5316\u8a98\u5c0e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304a\u3088\u3073\u67d3\u8272\u4f53\u5ea7\u89e3\u6790, \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4f50\u85e4\u6e09\u3001\u8c37\u672c\u6d69\u81f3\u3001\u8acb\u5ddd\u4eae\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30d8\u30ad\u30b9\u30c8\u8010\u6027\u5909\u7570\u7d30\u80de\u682a\u3092\u7528\u3044\u305f5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

\u30fbHossain MN, Fujii M, Ayusawa, D\uff1aMutants ES cells having a knock out hnRNP C1\/C2 show increased sensitivity to 5-halogenated deoxyuridine, \u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u4e09\u6728\u5065\u8f14\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u306e\u30d1\u30e9\u30b3\u30fc\u30c8\u8010\u6027\u5909\u7570\u4f53mev-4\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

\u30fbArivazhagan P, Mizutani E, Miki K, Fujii M, Ayusawa D\uff1aRole of phospholipids in induction of premature senescence in human cells\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002004\u5e74\u5ea6\u5927\u4f1a\uff082004\u5e743\u6708\uff1a\u5e83\u5cf6\uff09<\/strong><\/p>\n\n\n\n

2003\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u4f50\u85e4\u6e09\u3001\u9234\u6728\u654f\u548c\u3001\u91ce\u53e3\u5065\u6674\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a AT-hook\u86cb\u767d\u8cea\u306b\u3088\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8001\u5316\u8a98\u5c0e\u7cfb\u306e\u5897\u5f37\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002003\u5e74\u5ea6\u5927\u4f1a\uff082003\u5e74\uff13\u6708\uff1a\u85e4\u6ca2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95 \u9053\u5f66\u3001\u677e\u672c \u7531\u8cb4\u3001\u9234\u6728 \u654f\u548c\u3001\u77f3\u4e95 \u76f4\u660e\u3001\u9b8e\u6ca2 \u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u306e\u30d1\u30e9\u30b3\u30fc\u30c8\u8010\u6027\u5909\u7570\u4f53mev-4\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002003\u5e74\u5ea6\u5927\u4f1a\uff082003\u5e74\uff13\u6708\uff1a\u85e4\u6ca2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u6a4b\u3000\u88d5\u4e00\u90ce\u3001\u9053\u4e0b \u6c5f\u5229\u5b50\u3001\u8acb\u5ddd \u4eae\u3001\u524d\u5ddd \u76f4\u4e4b\u3001\u85e4\u4e95 \u9053\u5f66\u3001\u9b8e\u6ca2 \u5927\uff1a\u30d2\u30c8\u6b63\u5e38\u7d30\u80de\u306e\u8001\u5316\u306b\u4f34\u3046\u6838\u86cb\u767d\u8cea\u306e\u5909\u52d5\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002003\u5e74\u5ea6\u5927\u4f1a\uff082003\u5e74\uff13\u6708\uff1a\u85e4\u6ca2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7686\u5ddd\u5409\u3001\u4e2d\u6797\u4e00\u5f66\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001Stephen W. Scherer\u3001\u9b8e\u6ca2\u5927\uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u8001\u5316\u8a98\u5c0e\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002003\u5e74\u5ea6\u5927\u4f1a\uff082003\u5e74\uff13\u6708\uff1a\u85e4\u6ca2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9ad8\u5c71\u614e\u4e00\u3001Hossain,M.N.\u3001\u5c71\u7530\u4e9c\u5e0c\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u51fa\u82bd\u9175\u6bcdSaccharomyces cerevisiae\u306b\u304a\u3051\u308b5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u8010\u6027\u5909\u7570\u682a\u306e\u53d6\u5f97\u3068\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002003\u5e74\u5ea6\u5927\u4f1a\uff082003\u5e74\uff13\u6708\uff1a\u85e4\u6ca2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u5009\u6a4b\u654f\u88d5\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9234\u6728\u654f\u548c\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u306e\u8001\u5316\u8a98\u5c0e\u521d\u671f\u306b\u304a\u3051\u308b\u6838\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u86cb\u767d\u8cea\u306e\u89e3\u6790\u3001\u7b2c25\u56de\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\uff082002\u5e745\u6708\uff1a\u7b51\u6ce2\uff09<\/strong><\/p>\n\n\n\n

2002\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9234\u6728\u654f\u548c\u3001\u5ca9\u7530\u77e5\u5b50\u3001\u7686\u5ddd\u5409\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u7d30\u80de\u8001\u5316\u5fdc\u7b54\u907a\u4f1d\u5b50\u306e\u5927\u898f\u6a21\u63a2\u7d22\u3001\u7b2c25\u56de\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\uff082002\u5e745\u6708\uff1a\u7b51\u6ce2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u677e\u672c\u7531\u8cb4\u3001\u9234\u6728\u654f\u548c\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866bCaenorhabditis elegans\u3088\u308a\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u53d6\u5f97\u3001\u7b2c25\u56de\u65e5\u672c\u57fa\u790e\u8001\u5316\u5b66\u4f1a\uff082002\u5e745\u6708\uff1a\u7b51\u6ce2\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9234\u6728\u654f\u548c\u3001\u5ca9\u7530\u77e5\u5b50\u3001\u7686\u5ddd\u5409\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1aLarge Scale Screening for Senescence-Associated Genes with 5-Bromodeoxyuridine and Immortal Cell Lines\u3001First Conference on Functional Genomics of Ageing\uff082002\u5e74\uff14\u6708\uff1a\u30b9\u30da\u30a4\u30f3\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u7530\u4e2d\u83dc\u82d7\u3001\u57ce\u53e3\u6566\u5f18\u3001\u9234\u6728\u654f\u548c\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9b8e\u6ca2\u5927\uff1a Isolation of Mutants with Altered Sensitivity to Oxidative Stress in Nematode Caenorhabditis elegans, First Conference on Functional Genomics of Ageing\uff082002\u5e74\uff14\u6708\uff1a\u30b9\u30da\u30a4\u30f3\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u837b\u91ce\u79c0\u6a39\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1aRole of the Nuclear Matrix in the Senescence-Like Phenomenon Induced by 5-Bromodeoxyuridine in Hela Cells, First Conference on Functional Genomics of Ageing\uff082002\u5e74\uff14\u6708\uff1a\u30b9\u30da\u30a4\u30f3\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4f50\u85e4\u6e09\u3001\u91ce\u53e3\u5065\u6674\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u8a98\u5c0e\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002002\u5e74\u5ea6\u5927\u4f1a\uff082002\u5e743\u6708\uff1a\u4ed9\u53f0\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u85e4\u4e95\u9053\u5f66\u3001\u7530\u4e2d\u83dc\u82d7\u3001\u677e\u672c\u7531\u8cb4\u3001\u9234\u6728\u654f\u548c\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9b8e\u6ca2\u5927 \uff1a \u7dda\u866bCaenorhabditis elegans\u306e\u6d3b\u6027\u9178\u7d20\u611f\u53d7\u6027\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002002\u5e74\u5ea6\u5927\u4f1a\uff082002\u5e743\u6708\uff1a\u4ed9\u53f0\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5ca9\u7530\u77e5\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u5c0f\u7267\u5927\u7950\u3001\u7686\u5ddd\u5409\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927 \uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u7d30\u80de\u8001\u5316\u5fdc\u7b54\u907a\u4f1d\u5b50\u306e\u5b8c\u5168\u30ab\u30bf\u30ed\u30b0\u306e\u4f5c\u88fd\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u30002002\u5e74\u5ea6\u5927\u4f1a\uff082002\u5e743\u6708\uff1a\u4ed9\u53f0\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9234\u6728\u654f\u548c\u3001\u5ca9\u7530\u77e5\u5b50\u3001\u5c0f\u7267\u5927\u7950\u3001\u7686\u5ddd\u5409\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u7d30\u80de\u8001\u5316\u5fdc\u7b54\u907a\u4f1d\u5b50\u306e\u5927\u898f\u6a21\u63a2\u7d22\u3001\u65e5\u672c\u85ac\u5b66\u4f1a\u3000\u7b2c122\u5e74\u4f1a\uff082002\u5e743\u6708\uff1a\u5343\u8449\uff09<\/strong><\/p>\n\n\n\n

2001\u5e74<\/strong><\/p>\n\n\n\n

\u30fb\u9b8e\u6ca2\u5927\u3001\u9234\u6728\u654f\u548c\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u837b\u91ce\u79c0\u6a39\u3001\u85e4\u4e95\u9053\u5f66\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308b\u65b0\u898f\u300c\u6838\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u7406\u8ad6\u300d\u306e\u691c\u8a3c\u3001\u7b2c24\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\uff082001\u5e7412\u6708\uff1a\u6a2a\u6d5c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u91ce\u53e3\u5065\u6674\u3001\u4f50\u85e4\u6e09\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u7d30\u80de\u8001\u5316\u306b\u304a\u3051\u308bAT-hook\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f79\u5272\u306e\u89e3\u6790\u3001\u7b2c24\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\uff082001\u5e7412\u6708\uff1a\u6a2a\u6d5c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9234\u6728\u654f\u548c\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u837b\u91ce\u79c0\u6a39\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u95a2\u9023\u907a\u4f1d\u5b50\u8a98\u5c0e\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u7b2c24\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\uff082001\u5e7412\u6708\uff1a\u6a2a\u6d5c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u5009\u6a4b\u654f\u88d5\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a5-\u30cf\u30ed\u30b2\u30f3\u5316\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u62b5\u6297\u6027\u30de\u30a6\u30b9FM3A\u7d30\u80de\u5909\u7570\u682a\u306e\u5206\u96e2\u3068\u89e3\u6790\u3001\u7b2c24\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\uff082001\u5e7412\u6708\uff1a\u6a2a\u6d5c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u677e\u672c\u7531\u8cb4\u3001\u7530\u4e2d\u83dc\u82d7\u3001\u85e4\u4e95\u9053\u5f66\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9234\u6728\u654f\u548c\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866b(C.elegans)\u306b\u304a\u3051\u308b\u5bff\u547d\u5909\u7570\u4f53\u306e\u907a\u4f1d\u89e3\u6790\u3001\u7b2c24\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\uff082001\u5e7412\u6708\uff1a\u6a2a\u6d5c\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9234\u6728\u654f\u548c\u3001\u5ca9\u7530\u77e5\u5b50\u3001\u5927\u585a\u3044\u305a\u307f\u3001\u5927\u77f3\u6b66\u3001\u5c0f\u7267\u5927\u7950\u3001\u7686\u5ddd\u5409\u3001\u85e4\u4e95\u9053\u5f66, \u9b8e\u6ca2\u5927 \uff1a \u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u3092\u7528\u3044\u305f\u7d30\u80de\u8001\u5316\u8a98\u5c0e\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u3001\u7b2c74\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\uff082001\u5e748\u6708 \uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u4f50\u85e4\u6e09\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927 \uff1a\u30d6\u30ed\u30e2\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u8a98\u5c0e\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u7b2c74\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\uff082001\u5e748\u6708 \uff1a\u4eac\u90fd\uff09<\/strong><\/p>\n\n\n\n

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\u30fb\u837b\u91ce\u79c0\u6a39\u3001\u5185\u7aaa\u53cb\u7f8e\u3001\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u5927\uff1a BudR\u306b\u3088\u308bmyoD\u907a\u4f1d\u5b50\u767a\u73fe\u6291\u5236\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2001\u5e74\u5ea6\u5927\u4f1a\uff082001\u5e743\u6708\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u9053\u4e0b\u6c5f\u5229\u5b50\u3001\u677e\u6751\u76f4\u4eba\u3001\u5009\u6a4b\u654f\u88d5\u3001\u837b\u91ce\u79c0\u6a39\u3001\u9234\u6728\u654f\u548c\u3001\u85e4\u4e95\u9053\u5f66\u3001\u9b8e\u6ca2\u3000\u5927\uff1a5-\u30cf\u30ed\u30b2\u30f3\u5316\u30c7\u30aa\u30ad\u30b7\u30a6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u7d30\u80de\u8001\u5316\u306b\u4f34\u3044\u5909\u5316\u3059\u308b\u30af\u30ed\u30de\u30c1\u30f3\u69cb\u6210\u86cb\u767d\u8cea\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2001\u5e74\u5ea6\u5927\u4f1a\uff082001\u5e743\u6708\uff09<\/strong><\/p>\n\n\n\n

\u30fb\u7530\u4e2d\u83dc\u82d7\u3001\u85e4\u4e95\u9053\u5f66\u3001\u57ce\u53e3\u6566\u5f18\u3001\u9234\u6728\u654f\u548c\u3001\u77f3\u4e95\u76f4\u660e\u3001\u9b8e\u6ca2\u5927\uff1a\u7dda\u866b\uff08C.elegans\uff09\u306b\u304a\u3051\u308b\u5bff\u547d\u5909\u7570\u4f53\u306e\u89e3\u6790\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a2001\u5e74\u5ea6\u5927\u4f1a\uff082001\u5e743\u6708\uff09<\/strong><\/p>\n\n\n\n

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2000\u5e74<\/strong><\/p>\n\n\n\n

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\u5bfe\u5916\u6d3b\u52d5<\/strong><\/p>\n\n\n\n

1. \u6a2a\u6d5c\u7523\u5b66\u4ea4\u6d41\u30bb\u30df\u30ca\u30fc\u300c\u8001\u5316\u7814\u7a76\u304b\u3089\u4e0d\u8001\u9577\u5bff\u306e\u5b9f\u8df5\u3078\u300d\uff082006\u5e748\u670825\u65e5\uff09\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

2. ICHIBAN LIFETECH SOLUTIONS\u682a\u5f0f\u4f1a\u793e\u8a2d\u7acb\u3000\uff082006\u5e748\u670822\u65e5\uff09\u672c\u793e\u6a2a\u6d5c<\/strong><\/p>\n\n\n\n

3. \u30ea\u30ab\u30ec\u30f3\u30c8\u8b1b\u5ea7\u300c\u8001\u5316\u9632\u6b62\u306e\u79d1\u5b66\u300d\uff082004\u5e741-2\u6708\u3001\u30a2\u30fc\u30d0\u30f3\u30ab\u30ec\u30c3\u30b8\uff09\u4f01\u753b\u767a\u8868<\/strong><\/p>\n\n\n\n

4. \u56fd\u969b\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u300cInternational Workshop on Nuclear Dynamics\u300d\uff082002\u5e7412\u6708\uff1a\u6728\u539f\u751f\u7269\u5b66\u7814\u7a76\u6240\uff09\u958b\u50ac\uff08\u4f01\u753b\u59d4\u54e1\uff09<\/strong><\/p>\n\n\n\n

5. \u30ea\u30ab\u30ec\u30f3\u30c8\u8b1b\u5ea7\u300c\u6d3b\u6027\u9178\u7d20\u3068\u751f\u547d\u300d\u2014\u6210\u4eba\u75c5\u306e\u6700\u5f37\u5371\u967a\u56e0\u5b50\u306e\u8b0e\u3092\u89e3\u304f\uff082001\u5e742\u670823\u65e5-3\u67089\u65e5\u3001\u30a2\u30fc\u30d0\u30f3\u30ab\u30ec\u30c3\u30b8\uff09\u4f01\u753b\u767a\u8868<\/strong><\/p>\n\n\n\n

6. \u9ad8\u6821\u751f\u907a\u4f1d\u5b50\u64cd\u4f5c\u6280\u8853\u5b9f\u7fd2\u4f1a\u30002003\u5e747\u670823-25\u65e5<\/strong><\/p>\n\n\n\n

7. \u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u8b1b\u7fd2\u4f1a\u3000<\/strong><\/p>\n\n\n\n

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8. \u7814\u7a76\u6240\u4e00\u65e5\u516c\u958b\u30002000\u5e747\u670829\u65e5\uff08\u571f\uff092001\u5e747\u670828\u65e5\uff08\u571f\uff092002\u5e747\u670827\u65e5\uff08\u571f\uff092003\u5e747\u670826\u65e5\uff08\u571f\uff092004\u5e747\u670824\u65e5\uff08\u571f\uff092005\u5e747\u67082<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u7814\u7a76\u696d\u7e3e -\u8ad6\u6587\u767a\u8868- 2025\u5e74 \u30fbYoshimi Yamakami, Kyoko Morino, Robe […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-38","page","type-page","status-publish","hentry","post"],"_links":{"self":[{"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/38","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/comments?post=38"}],"version-history":[{"count":7,"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/38\/revisions"}],"predecessor-version":[{"id":427,"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/38\/revisions\/427"}],"wp:attachment":[{"href":"https:\/\/antiage.sci.yokohama-cu.ac.jp\/index.php\/wp-json\/wp\/v2\/media?parent=38"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}